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Symbol
Name
ID
Srf
serum response factor
MGI:106658
Phenotype annotations related to cardiovascular system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Gastrointestinal hemorrhage
Chylopericardium
Pulmonary lymphangiomyomatosis
Abnormality of the lymphatic system
Lymphadenopathy
Disease(s) Associated with SRF
lymphangioleiomyomatosis

Mouse Phenotypes
cardiovascular system phenotype
vascular smooth muscle hypotrophy
abnormal myocardium layer morphology
abnormal myocardial fiber morphology
abnormal intercalated disk morphology
trabecula carnea hypoplasia
disorganized myocardium
thin myocardium
persistent truncus arteriosus
abnormal fetal atrioventricular canal morphology
abnormal interventricular septum morphology
thin interventricular septum
ventricular septal defect
abnormal heart shape
cardiac hypertrophy
abnormal heart ventricle morphology
increased heart left ventricle size
abnormal interventricular groove morphology
dilated heart ventricle
abnormal pericardium morphology
distended pericardium
pericardial effusion
cardiac fibrosis
dilated cardiomyopathy
internal hemorrhage
decreased ventricle muscle contractility
abnormal cardiac muscle relaxation
irregular heartbeat
increased cardiomyocyte apoptosis
congestive heart failure
Availability Mouse Genotype
Srftm1Rmn/Srftm1Rmn
Tg(Tagln-cre)1Jomm/0  (conditional)
Srftm1Rmn/Srftm1Rmn
H2az2Tg(Wnt1-cre)11Rth/H2az2+  (conditional)
Srftm1Zli/Srftm1Zli
Tg(Myh7-cre)1Zli/0  (conditional)
Srftm1Zli/Srftm1Zli
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+  (conditional)
Srftm2.1Nor/Srftm2.1Nor
Tg(Myog-cre)1Eno/0  (conditional)
*
Srftm1Rjs/Srftm2.1Nor
Tg(Myh6-cre)2182Mds/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory